Microbial Products Trigger Autoimmune Ocular Inflammation
نویسندگان
چکیده
منابع مشابه
Microbial products trigger autoimmune ocular inflammation.
PURPOSE Microbial products stimulate the immune system by interacting with Toll-like receptors (TLR) on antigen-presenting cells. This study examined the hypothesis that microbial products, which function as TLR ligands, are playing a major role in triggering pathogenic autoimmunity. METHODS An experimental system was developed in which microbial TLR ligands were tested in vivo for their capa...
متن کاملOcular inflammation in autoimmune MRL/Mp mice.
Congenic mice of the MRL/Mp strain spontaneously develop an autoimmune connective tissue disease that shares immunologic and histopathologic features with the human disorders systemic lupus erythematosus, rheumatoid arthritis, and systemic vasculitis. The autoimmune disorder in these mice is markedly accelerated by the recessive gene lpr. Older MRL/Mp-lpr/lpr mice develop significant inflammato...
متن کاملMicrobial products trigger amino acid exudation from plant roots.
Plants naturally cycle amino acids across root cell plasma membranes, and any net efflux is termed exudation. The dominant ecological view is that microorganisms and roots passively compete for amino acids in the soil solution, yet the innate capacity of roots to recover amino acids present in ecologically relevant concentrations is unknown. We find that, in the absence of culturable microorgan...
متن کاملOcular Inflammation
Ocular inflammation has become a hot topic in ophthal-mology, involving also several areas of medicine: internal optic nerve. Management of ocular inflammation presents diagnostic and therapeutic challenges, ranging the etiology and prognosis from benign, self-limited conditions to organ-threatening disorders. Ocular inflammation is a component of eye surgery, sometimes leading to its complicat...
متن کاملOcular infection and inflammation.
Managing the inflamed or infected eye in the emergency setting presents a diagnostic and therapeutic challenge to the emergency physician; the causes and prognoses range from benign, self-limited illness to organ-threatening pathology. A careful history, with attention to comorbid illnesses and time course, is paramount, as is knowledge of the complete ophthalmologic examination. Much of the or...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Ophthalmic Research
سال: 2008
ISSN: 1423-0259,0030-3747
DOI: 10.1159/000119875